Association Of Dyslipidemia With Severity Of Meibomian Gland Dysfunction And Type Of Dry Eye Disease

Hubungan Dislipidemia Dengan Tingkat Keparahan Disfungsi Kelenjar Meibom Dan Jenis Penyakit Mata Kering

Abstract

Meibomian gland is physiologically involved in lipid secretion, thus abnormality of systemic lipid level is possibly related to meibomian gland lipid. Increased cholesterol level, mainly cholesterol ester, in secretion of meibomian gland is associated with pathology of MGD. This is the first population-based study assessing association of dyslipidemia with MGD and DED. This was a cross-sectional population-based study using consecutive sampling. Data was taken from database of Smart Health Study conducted  in Mendalanwangi, Sidorahayu, and Cepokomulyo Village, Malang. There were 867 subjects aged ≥ 40 years old with risk of MGD. Assessment of DED (OSDI score, TBUT, TM, and MGD) and dyslipidemia (level of TG and HDL) were performed. Majority of subjects were female with no DED or dyslipidemia. Most respondents had MGD grade 1. Patients with dyslipidemia had 1.4-fold risk for evaporative dry eye (EDE) compared to patients with normal lipid level [OR 1.417 (95% CI : 1.0-2.070)]. Patients with MGD had lower risk of aqueous deficiency dry eye (ADDE) [OR 0.160 (95% CI: 0.699 – 0.366)]. There was no significant association between dyslipidemia and MGD and DED. Patients with dyslipidemia had 1.4-fold risk of EDE compared to patients with normal lipid level.